def model SGLT1_BG as def import using "./units.cellml" for unit fmol_per_s using unit fmol_per_s; unit fmol using unit fmol; unit fA using unit fA; unit per_fmol using unit per_fmol; unit C_per_mol using unit C_per_mol; unit J_per_K_mol using unit J_per_K_mol; unit J_per_mol using unit J_per_mol; enddef; def import using "params_BG.cellml" for comp params_BG using comp params_BG; enddef; def comp SGLT1_BG as var t: second; var R: J_per_K_mol{ pub: in}; var T: kelvin{ pub: in}; var F: C_per_mol{ pub: in}; var K_Nai: per_fmol{ pub: in}; var q_init_Nai: fmol{ pub: in}; var K_Nao: per_fmol{ pub: in}; var q_init_Nao: fmol{ pub: in}; var K_Glci: per_fmol{ pub: in}; var q_init_Glci: fmol{ pub: in}; var K_Glco: per_fmol{ pub: in}; var q_init_Glco: fmol{ pub: in}; var K_1: per_fmol{ pub: in}; var q_init_1: fmol{ pub: in}; var K_2: per_fmol{ pub: in}; var q_init_2: fmol{ pub: in}; var K_3: per_fmol{ pub: in}; var q_init_3: fmol{ pub: in}; var K_4: per_fmol{ pub: in}; var q_init_4: fmol{ pub: in}; var K_5: per_fmol{ pub: in}; var q_init_5: fmol{ pub: in}; var K_6: per_fmol{ pub: in}; var q_init_6: fmol{ pub: in}; var V0_Vm: volt{ pub: in}; var z_z1: dimensionless{ pub: in}; var z_z2: dimensionless{ pub: in}; var z_z3: dimensionless{ pub: in}; var z_z4: dimensionless{ pub: in}; var kappa_r1: fmol_per_s{ pub: in}; var kappa_r2: fmol_per_s{ pub: in}; var kappa_r3: fmol_per_s{ pub: in}; var kappa_r4: fmol_per_s{ pub: in}; var kappa_r5: fmol_per_s{ pub: in}; var kappa_r6: fmol_per_s{ pub: in}; var kappa_r7: fmol_per_s{ pub: in}; var mu_Nai: J_per_mol; var v_Nai: fmol_per_s; var mu_Nao: J_per_mol; var v_Nao: fmol_per_s; var mu_Glci: J_per_mol; var v_Glci: fmol_per_s; var mu_Glco: J_per_mol; var v_Glco: fmol_per_s; var mu_1: J_per_mol; var v_1: fmol_per_s; var mu_2: J_per_mol; var v_2: fmol_per_s; var mu_3: J_per_mol; var v_3: fmol_per_s; var mu_4: J_per_mol; var v_4: fmol_per_s; var mu_5: J_per_mol; var v_5: fmol_per_s; var mu_6: J_per_mol; var v_6: fmol_per_s; var V_Vm: volt; var V_z1: volt; var I_z1: fA; var mu_z1: J_per_mol; var v_z1: fmol_per_s; var V_z2: volt; var I_z2: fA; var mu_z2: J_per_mol; var v_z2: fmol_per_s; var V_z3: volt; var I_z3: fA; var mu_z3: J_per_mol; var v_z3: fmol_per_s; var V_z4: volt; var I_z4: fA; var mu_z4: J_per_mol; var v_z4: fmol_per_s; var A_f_r1: J_per_mol; var v_r1: fmol_per_s; var A_r_r1: J_per_mol; var A_f_r2: J_per_mol; var v_r2: fmol_per_s; var A_r_r2: J_per_mol; var A_f_r3: J_per_mol; var v_r3: fmol_per_s; var A_r_r3: J_per_mol; var A_f_r4: J_per_mol; var v_r4: fmol_per_s; var A_r_r4: J_per_mol; var A_f_r5: J_per_mol; var v_r5: fmol_per_s; var A_r_r5: J_per_mol; var A_f_r6: J_per_mol; var v_r6: fmol_per_s; var A_r_r6: J_per_mol; var A_f_r7: J_per_mol; var v_r7: fmol_per_s; var A_r_r7: J_per_mol; var q_Nai: fmol{ init: q_init_Nai}; var q_Nao: fmol{ init: q_init_Nao}; var q_Glci: fmol{ init: q_init_Glci}; var q_Glco: fmol{ init: q_init_Glco}; var q_1: fmol{ init: q_init_1}; var q_2: fmol{ init: q_init_2}; var q_3: fmol{ init: q_init_3}; var q_4: fmol{ init: q_init_4}; var q_5: fmol{ init: q_init_5}; var q_6: fmol{ init: q_init_6}; mu_Nai = R*T*ln(K_Nai*q_Nai); ode(q_Nai,t) = v_Nai; mu_Nao = R*T*ln(K_Nao*q_Nao); ode(q_Nao,t) = v_Nao; mu_Glci = R*T*ln(K_Glci*q_Glci); ode(q_Glci,t) = v_Glci; mu_Glco = R*T*ln(K_Glco*q_Glco); ode(q_Glco,t) = v_Glco; mu_1 = R*T*ln(K_1*q_1); ode(q_1,t) = v_1; mu_2 = R*T*ln(K_2*q_2); ode(q_2,t) = v_2; mu_3 = R*T*ln(K_3*q_3); ode(q_3,t) = v_3; mu_4 = R*T*ln(K_4*q_4); ode(q_4,t) = v_4; mu_5 = R*T*ln(K_5*q_5); ode(q_5,t) = v_5; mu_6 = R*T*ln(K_6*q_6); ode(q_6,t) = v_6; V_Vm=V0_Vm; mu_z1=z_z1*F*V_z1; I_z1=z_z1*F*v_z1; mu_z2=z_z2*F*V_z2; I_z2=z_z2*F*v_z2; mu_z3=z_z3*F*V_z3; I_z3=z_z3*F*v_z3; mu_z4=z_z4*F*V_z4; I_z4=z_z4*F*v_z4; v_r1 = kappa_r1*(exp(A_f_r1/(R*T)) - exp(A_r_r1/(R*T))); v_r2 = kappa_r2*(exp(A_f_r2/(R*T)) - exp(A_r_r2/(R*T))); v_r3 = kappa_r3*(exp(A_f_r3/(R*T)) - exp(A_r_r3/(R*T))); v_r4 = kappa_r4*(exp(A_f_r4/(R*T)) - exp(A_r_r4/(R*T))); v_r5 = kappa_r5*(exp(A_f_r5/(R*T)) - exp(A_r_r5/(R*T))); v_r6 = kappa_r6*(exp(A_f_r6/(R*T)) - exp(A_r_r6/(R*T))); v_r7 = kappa_r7*(exp(A_f_r7/(R*T)) - exp(A_r_r7/(R*T))); v_Nai = v_r5*2{dimensionless}; v_Nao = - v_r1*2{dimensionless}; v_Glci = v_r4; v_Glco = - v_r2; v_1 = v_r6 - v_r1; v_2 = v_r1 - v_r2+v_r7; v_3 = v_r2 - v_r3; v_4 = v_r3 - v_r4; v_5 = v_r4+v_r7 - v_r5; v_6 = v_r5 - v_r6; V_z1 = V_Vm; v_z1 = v_r1; V_z2 = V_Vm; v_z2 = v_r1; V_z3 = V_Vm; v_z3 = v_r6; V_z4 = V_Vm; v_z4 = v_r6; A_f_r1 = mu_Nao*2{dimensionless}+mu_1 - mu_z2; A_r_r1 = mu_2+mu_z1; A_f_r2 = mu_Glco+mu_2; A_r_r2 = mu_3; A_f_r3 = mu_3; A_r_r3 = mu_4; A_f_r4 = mu_4; A_r_r4 = mu_Glci+mu_5; A_f_r5 = mu_5; A_r_r5 = mu_Nai*2{dimensionless}+mu_6; A_f_r6 = mu_6 - mu_z4; A_r_r6 = mu_1+mu_z3; A_f_r7 = mu_2; A_r_r7 = mu_5; enddef; def map between params_BG and SGLT1_BG for vars R and R; vars T and T; vars F and F; vars K_Nai and K_Nai; vars q_init_Nai and q_init_Nai; vars K_Nao and K_Nao; vars q_init_Nao and q_init_Nao; vars K_Glci and K_Glci; vars q_init_Glci and q_init_Glci; vars K_Glco and K_Glco; vars q_init_Glco and q_init_Glco; vars K_1 and K_1; vars q_init_1 and q_init_1; vars K_2 and K_2; vars q_init_2 and q_init_2; vars K_3 and K_3; vars q_init_3 and q_init_3; vars K_4 and K_4; vars q_init_4 and q_init_4; vars K_5 and K_5; vars q_init_5 and q_init_5; vars K_6 and K_6; vars q_init_6 and q_init_6; vars V0_Vm and V0_Vm; vars z_z1 and z_z1; vars z_z2 and z_z2; vars z_z3 and z_z3; vars z_z4 and z_z4; vars kappa_r1 and kappa_r1; vars kappa_r2 and kappa_r2; vars kappa_r3 and kappa_r3; vars kappa_r4 and kappa_r4; vars kappa_r5 and kappa_r5; vars kappa_r6 and kappa_r6; vars kappa_r7 and kappa_r7; enddef; enddef;